Training
M.D., Magna Cum Laude, Autonomous University
of Barcelona Medical School,
Spain, 1981-1986
PhD., Pharmacoepidemiology,
Autonomous University
of Barcelona Medical School,
Spain, 1987-1990
Professional experience
1987-90
Pharmacoepidemiology Unit
Hospital Vall
d’Hebron, Spanish Ministry
of Health, Barcelona,
Spain
1987-90
Teaching Assistant, Clinical Pharmacology, Autonomous University
of Barcelona, Barcelona,
Spain
1990-92
Teaching Assistant, Biostatistics, Autonomous University
of Barcelona, Barcelona,
Spain
1992-93
Assistant Professor, Preventive Medicine, Autonomous University
of Barcelona, Barcelona,
Spain
1993-94
Visiting Scientist, Unit of Field and Intervention Studies, International
Agency for Research On Cancer, Lyon, France
1994-07
Associate Professor, Preventive Medicine, Autonomous University of Barcelona, Barcelona, Spain
1994-08
Epidemiologist, Cancer Epidemiology Service, Catalan Institute of Oncology, Barcelona, Spain
2006- Visiting
Professor, Dep. Internal Medicine, University
of Michigan, Ann Arbor, US
2007-
Associate Professor, Preventive Medicine, University of Barcelona, Barcelona, Spain
2008- Unit
chief, Unit of Biostatistics and Bioinformatics, Catalan Institute of Oncology,
Barcelona, Spain
Research areas of interest
- Cancer
epidemiology
o
Descriptive epidemiology. Cancer registration. Time trends,
geographical distribution, incidence predictions, relative survival.
o
Analytical epidemiology. Oral contraceptives and cervical
cancer. Dietary and environmental risk factors for colorectal cancer.
o
Genetic epidemiology of colorectal cancer. Genetic
susceptibility, polymorphisms, gene-environment interactions. Familial cancer.
o
Molecular epidemiology of colorectal cancer. Genomic
instability, microsatellite instability, methylation. Expression profiles from microarray.
- Biostatistics and
bioinformatics
o
Sequential methods
o
Statistical
methods for genetic epidemiology (SNPstats)
o
Statistical
methods for the analysis of microarray data
o
Systems biology methods
Selected recent
publications
- Tenesa A, et
al. Genome-wide association scan identifies a colorectal cancer
susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet. 2008 Mar 30
- Sole X, et al. Genetic and genomic analysis modeling of germline c-MYC overexpression
and cancer susceptibility. BMC
Genomics. 2008;9:12.
- Gonzalez JR, et al. Maximizing association
statistics over genetic models. Genet
Epidemiol. 2008;32:246-54.
- Menéndez M, et
al. Functional characterization of the novel APC N1026S variant associated
with attenuated familial adenomatous polyposis. Gastroenterology.
2008;134:56-64.
- Pujana MA, et
al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007;39:1338-49.
- Gruber SB, Moreno
V, et al. Genetic Variation in 8q24 Associated with Risk of Colorectal
Cancer. Cancer Biol
Ther. 2007;6
- Zhang L, et al. Accounting for error due
to misclassification of exposures in case-control studies of
gene-environment interaction. Stat
Med. 2007
- Salaverria I, et
al. Specific Secondary Genetic Alterations in Mantle Cell Lymphoma Provide
Prognostic Information Independent of the Gene Expression-Based
Proliferation Signature. J Clin Oncol. 2007;25:1216-22
- Gonzalez JR, et al. SNPassoc: an R
package to perform whole genome association studies. Bioinformatics. 2007;23:644-5.
- Sole X, et al. SNPStats: a web tool for
the analysis of association studies. Bioinformatics.
2006: 22: 1928-9
- Moreno V, et al. Polymorphisms in genes of nucleotide and base
excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res. 2006; 12: 2101-8
- Moreno V, et al. Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related
to colorectal cancer. Int J Cancer.
2005; 113:683-6.
- Cox DG, et al. Polymorphisms in prostaglandin synthase
2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J
Cancer 2004; 91:339-43
- Gemignani F, Moreno V, Landi S, et al. A TP53 polymorphism is associated with
increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene 2004; 23:1954-6
- Landi S, Moreno V, et al. Association of common polymorphisms in inflammatory genes interleukin
(IL)6, IL8, tumor necrosis factor alpha, NFKB1, and
peroxisome proliferator-activated receptor gamma with
colorectal cancer. Cancer Res 2003 63: 3560-6.
- Moreno V, et al. Effect of oral contraceptives on risk of cervical
cancer in women with human papillomavirus
infection: the IARC multicentric case-control
study. Lancet 2002 ;359:1085-92
Search
PubMed for recent publications
Research projects
-
Proteomic profiles for diagnostic
and prognostic in colorectal cancer
-
Risk of colorectal cancer in
relation to water disinfection products – HiWate /
ENTERICOS Study
-
Polymorphisms in DNA repair genes in
colorectal cancer
-
Molecular Epidemiology of Colorectal
Cancer – MECC Study
-
Grape antioxidant dietary fibre and polyphenolic fractions in colorectal cancer prevention –
PREVENCOL Study
-
APC expression in familial adenomatous polyposis
-
Genetic instability and colorectal
cancer
-
Screening for colorectal cancer
-
Gene-environment interactions in
colorectal cancer
-
Implementation of statistical and
bioinformatics web tools
Research Support
Identification
and validation of serum proteomic biomarkers for diagnosis and prognosis in
colorectal cancer
The project aim is to find new
plasma protein biomarkers for diagnosis and prognosis of colorectal cancer.
Plasma samples from 405 patients diagnosed of colorectal cancer during 1996-98
and 344 controls recruited simultaneously at the same hospital will be analyzed
for proteomic spectra with matrix-assisted laser desorption
ionization time-of-flight (MALDI-TOF) mass spectrometry.
PI FIS 05/1006
(2006-08) Fondo de Investigaciones de la
Seguridad Social, Instituto de Salud Carlos III, Spanish Ministry of Health
Role of
polymorphisms in DNA repair genes in colorectal cancer
The main
objective is to analyze the genetic predisposition to suffer colorectal cancer,
sporadic and hereditary, determined by polymorphisms in a series of genes
implied in DNA repair. Secondary objectives: a) to investigate interactions
between these genes and environmental expositions (diet, alcohol, tobacco and
drugs). b) to assess the prognosis value of these polymorphisms and their
possible interaction with treatments.
PI FIS 03/0114 (2004-06) Fondo de Investigaciones
de la Seguridad Social,
Instituto de Salud Carlos III, Spanish Ministry of Health
Assessment
of the scientific bases for the use of grape antioxidant dietary fibre and polyphenolic fractions in colorectal cancer prevention.
The goal of
this proposal is to test whether the ingestion of dietary components of high polyphenolic content may be related to any preventive
activity against colorectal cancer. The dietary polyphenols
acting on the colon epithelium may not be those originally ingested because
they may suffer modifications during their transit along the intestinal tract,
especially by colonic bacterial fermentation. Polyphenolic
components of lower size may be absorbed in the small intestine before getting
to the colon. The project proposes the evaluation of the possible chemopreventive action owed to the species actually in
contact with the colonic epithelium after the ingestion of polyphenols.
Co-investigator
(PI: G Capella) SAF0402667 (2004-06) Spanish
Ministry of Education and Science
Analysis of
APC expression in familial adenomatous polyposis (fap). Contribution to tumorigenesis and diagnostic applications.
The project
aims are: 1 To study the relative contribution of abnormalities in RNA and
protein levels to the development of classical and attenuated FAP. 2 To study
if RNA and normal and mutant protein levels correlate with genotypic and
phenotypic variables. 3. To study if RNA and protein levels help in the
characterization of mutations of unknown malignant potential. 4. To assess the
feasibility of a novel molecular diagnostic strategy based on DNA, RNA and
protein analyses.
Co-investigator
(PI: G Capella) Research in oncology (2004-06) La
Caixa
Genetic
instability and colorectal cancer: Molecular profiles and identification of
implicated genes
Genetic
instability is an essential trait of tumor initiation
and progression. The pattern of genetic alterations (at the DNA, RNA or protein
levels) present in tumor cells is directly related to
the type of underlying instability. Its identification and characterization may
be useful in establishing the molecular basis of genetic instability and hence
of tumor evolution. Aims: Identification of the
molecular basis of genetic instability of human colorectal tumors.
Identification of novel genes involved in human colorectal tumorigenesis.
Co-investigator
(PI G Capella) SAF2000-0081-C02.02 (2001-03)
Spanish Ministry of Education and Science
