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COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

Tipo de Publicación:

Journal Article

Autores:

Tomlinson, IP; Dunlop, M; Campbell, H; Zanke, B; Gallinger, S; Hudson, T; Koessler, T; Pharoah, PD; Niittymäki, I; Tuupanen, S; Aaltonen, LA; Hemminki, K; Lindblom, A; Försti, A; Sieber, O; Lipton, L; van Wezel, T; Morreau, H; Wijnen, JT; Devilee, P; Matsuda, K; Nakamura, Y; Castellví-Bel, S; Ruiz-Ponte, C; Castells, A; Carracedo, A; Ho, JW; Sham, P; Hofstra, RM; Vodicka, P; Brenner, H; Hampe, J; Schafmayer, C; Tepel, J; Schreiber, S; Völzke, H; Lerch, MM; Schmidt, CA; Buch, S; Moreno, V; Villanueva, CM; Peterlongo, P; Radice, P; Echeverry, MM; Velez, A; Carvajal-Carmona, L; Scott, R; Penegar, S; Broderick, P; Tenesa, A; Houlston, RS

Origen:

British journal of cancer, Volumen 102, Ejemplar 2, p.447-54 (2010)

URL:

http://dx.doi.org/10.1038/sj.bjc.6605338

Resumen:

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.


Pubmed ID: 19920828