Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil.

Publication Type:

Journal Article

Authors:

Páez, D; Paré, L; Altés, A; Sancho-Poch, FJ; Petriz, L; Garriga, J; Monill, JM; Salazar, J; del Rio, E; Barnadas, A; Marcuello, E; Baiget, M

Source:

Journal of cancer research and clinical oncology, Volume 136, Issue 11, p.1681-9 (2010)

URL:

http://dx.doi.org/10.1007/s00432-010-0826-7

Abstract:

Chemoradiotherapy using 5-fluorouracil has shown to be effective treatment for rectal cancer. Thymidylate synthase (TS) is an important target enzyme for the fluoropyrimidines. However, the predictive role of TS levels in early stage rectal cancer is not yet well understood. We analyzed the value of TS gene polymorphisms as a predictive marker in patients with stage II and III rectal cancer treated with preoperative concomitant radiotherapy and fluoropyrimidine-based chemotherapy.

Pubmed ID: 20165956