High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation.

Publication Type:

Journal Article

Authors:

Mukherjee, B; Rennert, G; Ahn, J; Dishon, S; Lejbkowicz, F; Rennert, HS; Shiovitz, S; Moreno, V; Gruber, SB

Source:

Gastroenterology, Volume 140, Issue 7, p.1919-26 (2011)

URL:

http://linkinghub.elsevier.com/retrieve/pii/S0016-5085(11)00321-0

Abstract:

The MSH2 A636P mutation is a founder mutation in Ashkenazi Jews that causes Lynch syndrome, with a prevalence of 0.4%-0.7%. Estimates of age-specific cumulative risk and lifetime risk for colorectal cancer (CRC) and endometrial cancer (EC) specific to carriers of this mutation are not available.

Pubmed ID: 21419771