Identification of novel candidate genes

Title: Identification of novel candidate genes using gene regulatory networks (FIS PI081635)

Period: 2009-11

Financing Entity: Fondo de Investigaciones de la Seguridad Social, Instituto de Salud Carlos III, Spanish Ministry of Health (FIS)

Principal Investigator: Victor Moreno

Description:  A new methodology is proposed to identify new genetic markers of susceptibility and/or prognosis in colorectal cancer. It is based on the analysis of complex data from SNPs, CNV and expression, combined with external sources through techniques of systems biology. Paired normal mucosa and tumor samples from 100 individuals will be analyzed for expression with microarrays. In the same subjects, genetic variability (SNPs and CNV) be analyzed using 500K chips and, in tumors, allelic imbalances with aCGH. Gene expression data, variation data, and other external data sources available as gene ontology, pathways and literature will be combined using network theory to identify relationships between genes.